Application of CT-guided intracavitary/freehand interstitial brachy-therapy in radical radiotherapy for cervical cancer
Objective To investigate the clinical application of three-dimensional intracavitary/free-hand interstitial bra-chytherapy technique in radical radiotherapy for cervical cancer.Methods A retrospective study was conducted on the clinical data of patients with cervical cancer who underwent radical radiotherapy using CT-guided three-dimensional in-tracavitary/free-hand interstitial brachytherapy technique in The Affiliated Cancer Hospital of Nanjing Medical University from April 2019 to September 2021.The short-term efficacy and adverse reactions were analyzed,and the independent pre-dictors affecting short-term efficacy were evaluated by logistic risk regression model.Results A total of 182 patients were included,and all patients successfully completed the treatment.Clinical efficacy assessment performed 3 months after treat-ment revealed an overall response rate of 90.65％;the incidence of grade 3 and 4 adverse reactions in the lower gastrointest-inal tract was 4.4％during treatment.After reclassifying stage ⅢC patients according to the International Federation of Gynecology and Obstetrics(FIGO)2009 staging system and including factors affecting the stage,it was found that the tu-mor volume before brachytherapy was the main factor affecting the clinical efficacy of patients at this stage(P=0.004).Conclusion As a key method in radical radiotherapy for cervical cancer,three-dimensional intracavitary/free-hand intersti-tial brachytherapy technique is safe and effective and can be quickly popularized in primary hospitals beyond regional can-cer centers for cervical cancer brachytherapy.
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