Braided silk fibroin fiber artificial ligaments with reinforced mechanical properties and delayed degradation
Artificial ligament products exhibit various drawbacks in clinical applications,including non-degradability,stress shielding,mid-to long-term fatigue relaxation,and chronic inflammation.Therefore,the development of biodegradable artificial ligament materials with excellent mechanical properties represents the future direction of new-generation artificial ligaments.In the present study,an artificial ligament(AL)prototype with"shell-core"structure was designed through the use of silk fibroin fibers as raw materials,and AL was coated with polyurethane(PU)solution mixed with nano-hydroxyapatite(Hap)to obtain coated artificial ligament(CAL)materials.Furthermore,morphology,microstructure,mechanical properties,degradability,cell and tissue compatibility of the CAL were systematically characterized.The results demonstrate a regular"shell-core"structure,smooth surface,and uniform pores.Compared to AL,the mechanical properties of the CAL were significantly improved(P＜0.05),and the degradation rate in vitro was significantly delayed.Furthermore,the results of cell and tissue compatibility tests indicate that the CAL exhibits satisfactory cell and tissue compatibility,and mild inflammatory reaction.This study provides a theoretical basis and practical reference for development of new high-strength biodegradable artificial ligament products.
万方数据
维普
