Folic acid modified copper oxide nanoparticles coated with polydopamine for inhibition of tumor cell growth
Copper oxide nanoparticles(CuO NPs)with the size of about 10 nm were prepared by precipitation transformation method,and CuO@PDA-FA NPs were synthesized by polymerization of dopamine hydrochloride(DA HCl)and modification of folic acid(FA)on its surface.The morphology and properties of the nanoparticles were characterized by transmission electron microscope,infrared spectrometer,nano-particle size potential analyzer and X-ray photoelectron spectroscopy.The results show that CuO@PDA-FA NPs with a particle size of about 190 nm are prepared.The degradation of methylene blue and glucose oxide confirmed that the material has peroxidase(POD)activity and glucose oxidase(GOD)activity.Near-infrared photothermal conversion experiments show that it has good photothermal effect and photothermal stability.The results of in vitro cytotoxicity test,cell uptake test and reactive oxygen generation test show that CuO@PDA-FA NPs can actively target tumor cells and kill tumor cells through the synergistic effect of photothermal therapy(PTT),chemical dynamic therapy(CDT)and starvation therapy(ST).
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