Preparation and antimicrobial property of phospholipid-modified gallium-based metal-organic frameworks
The overuse of antibiotics has the effect of accelerating the evolution of bacteria and the development of super-resistant bacteria.Consequently,there is an urgent need to develop new and efficient non-antibiotic-based antimicrobial agents.The Ga-TCPP framework(Frameworks)materials(GaTF)were prepared by a self-assembly method using gallium chloride(GaCl3)and tetrakis(4-carboxyphenyl)porphyrin(TCPP)as raw materials.GaTF exhibited dual antimicrobial activities,comprising gallium ions and photodynamic forces.The GaTF@PC was modified on its surface using phosphatidylcholines(PC)to achieve good biocompatibility.GaTF@PC can effectively produce single-linear oxygen when irradiated with a 655 nm light source and gradually dissociates in phosphate buffer to release Ga3+.The effects of material concentration and light intensity on antimicrobial properties were investigated using Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)as experimental strains.The antimicrobial experiments demonstrated a positive correlation between the antimicrobial effect of GaTF@PC and both the material concentration and light intensity.At a concentration of 30 μg·mL-1,irradiation with a 655 nm light source at a light intensity of 100 mW·cm-2 for 10 minutes resulted in antibacterial rates of over 99％for both E.coli and S.aureus.
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