Preparation and performance of a multifunctional braided suture 5-Fu@CHA-TA/PLA
Multifunctional sutures have become the research hots due to minimize the inflammation of the injured skin tissue,inhibit scar and promote the physiological healing of the wound clinically.In this study,tannic acid(TA)-enhanced acylated hyaluronic acid(CHA)was synthesized and used to prepare functional sutures combined with 5-fluorouracil(5-Fu).The 7-strand poly(lactic acid)(PLA)composite yarn-based braided sutures were impregnated into 5-Fu@CHA-TA hydrogel by dip-coating-ultraviolet photoluminescence coupling method.Finally,5-Fu@CHA-TA/PLA multifunctional sutures were prepared.The SEM results showed that 5-Fu@CHA-TA gel could be uniformly coated on the surface of PLA suture.The in vitro results of antioxidant,hemolysis,and antibacterial tests showed that the functionalized suture had safe and stable antioxidant properties,blood compatibility,and prominent antibacterial effect.Moreover,the friction test showed that the friction of 5-Fu@CHA-TA/PLA suture was significantly lower than that of braided PLA suture,which would help to reduce the friction and drag of injured tissue.Tests on the stability of the coating showed that the hydrogel remained on the braided suture after several suturing operations,ensuring that the suture could perform its intended function upon implantation in the body.In addition,the results of cytocompatibility test in vitro show that the functional sutures present good cytocompatibility,and the inhibitory rate of released 5-Fu on fibroblasts reached 65.48%,which has the potential to significantly inhibit tissue proliferation.This research provides a potential direction for developing functional sutures.
万方数据
维普
