Expression and Significance of PLOD1 and NFE2L3 in Colorectal Cancer Tissues
Objective To investigate the expression and significance of procollagen lysine 2-oxoglutarate 5-dioxygenase 1(PLOD1)and nuclear factor E2-related factor 3(NFE2L3)in colorectal cancer tissues.Methods A prospective study was conducted on 90 patients with colorectal cancer admitted to our hospital from September 2020 to June 2021.Cancer tissues and adjacent tissues were taken to detect the expression levels of PLOD1 and NFE2L3.After 2 years of follow-up,the patients were divided into two subgroups ac-cording to the follow-up results,namely metastasis group(20 cases)and non-metastasis group(70 cases).The general clinical characteristics and the expression levels of PLOD1 and NFE2L3 in the 2 groups were compared,and the predictive value of PLOD1 and NFE2L3 for colorectal cancer metastasis was analyzed by logistic regression analysis.Results The positive expression rate and relative expression amount of PLOD1 and NFE2L3 in colorectal cancer tissues were higher than those in adjacent tissues(P＜0.05).There were no significant differences in gender,age,body mass index(BMI),tumor location and tumor diameter between the metastasis group and the non-metastasis group(P＞0.05).There were significant differences in clinical stage,tissue differentiation,and positive rates of PLOD1 and NFE2L3 between the metastasis group and the non-metastasis group(P＜0.05).The values of indexes with statistical differ-ences in univariate analysis were assigned,and the final Logistic regression analysis showed that clinical stage,degree of tissue differentiation,positive expressions of PLOD1 and NFE2L3 were independent influ-encing factors of colorectal cancer metastasis(P＜0.05).Conclusion The expression levels of PLOD1 and NFE2L3 in cancer tissues of colorectal cancer patients were significantly upregulated,and their expres-sions were closely related to the metastasis of colorectal cancer.PLOD1 and NFE2L3 can be considered as the molecular markers of colorectal cancer metastasis.
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