Expression of Survivin in Colon Tissues and Its Relationship with Severity of Tissue Lesions
Objective To analyze the expression of Survivin in colon tissues and its relationship with the severity of tissue lesions.Methods Intestinal tissue specimens of 126 patients with colonic lesions ad-mitted to our hospital from October 2021 to November 2022 were examined to analyze Survivin protein ex-pression score and positive expression rate of intestinal tissues and normal tissues adjacent to the lesions in different types of colonic lesions,and their correlation with the severity of the lesions.Results The Sur-vivin protein expression score and positive rate in colon cancer and colon polyp tissues were higher than those in the normal colon tissues(P＜0.05).The Survivin protein expression score and positive rate in colon cancer tissues were higher than those in colon polyp tissues(P＜0.05).There were no significant differences in the Survivin protein expression score and positive expression rate of colon cancer patients with different gross types(ulcer type,infiltrating type and eminence type)(P＞0.05).The Survivin pro-tein expression score and positive expression rate were significantly different in colon cancer patients with different TNM stages(P＜0.05).Among them,colon cancer of stage Ⅲ was significantly higher than stage Ⅰ and stage Ⅱ,and stage Ⅱ was higher than stage Ⅰ(P＜0.05).Kendall correlation analysis showed that Survivin expression was positively correlated with TNM stage of colon cancer(P＜0.05).Conclusion Survivin expression is significantly different in different colon tissues,and the Survivin ex-pression level is the highest in colon cancer tissues,which is correlated with the severity of the lesions.
Colon specimenSurvivin proteinExpressColon cancerPolyp of colon
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