Influence of Full Nutritional Support on Therapeutic Effect,Tolerance and Nutritional Status of Patients with Rectal Cancer Undergoing Neoadjuvant Concurrent Chemoradiotherapy
Objective To explore the influence of full nutritional support on the therapeutic effect,toler-ance and nutritional status of patients with rectal cancer undergoing neoadjuvant concurrent chemoradio-therapy.Methods A prospective study was conducted on 84 rectal cancer patients undergoing neoadju-vant concurrent chemoradiotherapy admitted to our hospital from February 2021 to February 2023.They were divided into the study group and the control group according to the random number table method,with 42 cases in each group.The control group was given routine nursing and nutritional intervention,while the study group was given full nutritional support.On the basis of the control group,the study group was given oral enteral nutrition(Ensure)daily throughout the treatment.The therapeutic effect,tol-erance,nutritional status and adverse reactions of the two groups were compared.Results The two groups of patients successfully completed surgical treatment after neoadjuvant chemoradiotherapy.The T stage and N stage decline rates after neoadjuvant chemoradiotherapy in the study group(59.52％,54.76％)were higher than those in the control group(35.71％,30.95％)(P＜0.05).There was no sig-nificant difference in the R0 resection rate between the study group and the control group(97.62％,95.24％)(P＞0.05).The anal sphincter preservation rate in the study group(64.29％)was higher than that in the control group(40.48％)(P＜0.05).Compared with the control group,the interruption rate of chemoradiotherapy in the study group was lower(P＜0.05).Compared with before intervention,the changes of prealbumin(PA),albumin(ALB),hemoglobin(Hb)in the study group after intervention were not significant(P＞0.05),only body mass index(BMI)was significantly decreased(P＜0.05).After intervention,PA,ALB,Hb and BMI in the control group were significantly decreased(P＜0.05).After intervention,the comparison between the two groups showed that PA,ALB,Hb and BMI in the study group were significantly lower than those in the control group(P＜0.05).There was no significant difference in the incidence of acute gastrointestinal reaction no less than level 3 and hand-foot syndrome be-tween the two groups(P＞0.05).The incidence of bone marrow suppression and acute radiation proctitis no less than level 3 in the study group were lower than those in the control group(P＜0.05).Conclu-sion Full nutritional support for rectal cancer patients with neoadjuvant concurrent chemoradiotherapy can effectively improve the therapeutic effect and tolerance,improve the nutritional status of patients and reduce adverse reactions.
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