Mechanism of Professor GONG Yi's Core Medication in Treating Senile Constipation Based on Network Phar-macology
Objective To explore the mechanism of Professor GONG Yi's core medication in the treat-ment of senile constipation based on network pharmacology.Methods The core drugs Baizhu(Atractyl-odis Macrocephalae Rhizoma),Dangshen(Codonopsis Radix),Huangqi(Astragali Radix),Danggui(Angel-icae Sinensis Radix)and Ziwan(Asteris Radix Et Rhizoma)and the targets of diseases were retrieved from databases of TCMSP,Drugbank,TTD,Disgenet and GeneCards.The intersection targets were obtained by using Venny 2.l,and then PPI analysis was performed in String.The visualization and GO,KEGG enrich-ment analysis were completed by using Cytoscape 3.7.1 and Metascape database.Results Total 41 ac-tive ingredients,217 drug targets,1079 disease targets and 94 intersection targets were obtained.Luteolin,kaempferol and quercetin,etc.were included in the 41 active ingredients.AKT1,IL6 and TNF,etc.were included in the 217 core targets.The signal pathways were mainly cancer pathway,MAPK pathway,PI3K-AKT pathway and AGE-RAGE pathway.Conclusion Professor GONG Yi treats senile constipation with Baizhu,Dangshen,Huangqi,Danggui and Ziwan as the core drugs.Further experiments are needed to verify that it may play a role through multi-target and multi-channel synergistic interaction.
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