Short-Term Efficacy and Safety of Fecal Microbiota Transplantation in Treating Mixed Type of Irritable Bowel Syndrome
Objective To investigate the short-term efficacy and safety of fecal microbiota transplantation in the treatment of patients with mixed type of irritable bowel syndrome(IBS-M).Methods Total 40 patients with IBS-M admitted to the Department of Gastroenterology of Jiangmen People's Hospital from April 2021 to December 2022 were randomly divided into the observation group and the control group,with 20 patients in each group.The control group was treated with bifidobacterium quadruple viable bacte-ria while the observation group was treated with fecal microbiota transplantation.The short-term efficacy of the two groups was compared,including IBS severity(IBS-SSS)score,IBS quality of life(IBS-QOL)score,gastrointestinal symptom rating scale(GSRS)score,intestinal flora diversity(Chao1 and Shannon indexes)and safety.Results At 8 weeks and 3 months after treatment,IBS-SSS and GSRS scores were significantly decreased,IBS-QOL scores were increased,and all the scores were better in the observation group than in the control group(P＜0.05).Chao1 and Shannon indexes in the observation group were higher than those in the control group after treatment,and indexes in the observation group at 3 months af-ter treatment were higher than those at 8 weeks after treatment(P＜0.05).There was no significant difference in safety assessment between the two groups(P＞0.05).Conclusion Fecal microbiota transplantation can improve the short-term clinical efficacy and increase the diversity of intestinal flora in IBS-M patients with good safety.
Mixed type of irritable bowel syndromeFecal microbiota transplantationShort-term effica-cySafety
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