Objective To analyze the clinical value of fecal immunochemical test(FIT)combined with cancer antigen 125(CA125)and serum alkaline phosphatase(ALP)in the diagnosis of colorectal cancer.Methods Total 62 patients diagnosed with colorectal cancer in our hospital from January 2022 to March 2023 were set as the observation group,and 75 volunteers without the risk of colorectal cancer in the same period were set as the control group,and the clinical data of the two groups were collected.The positive rates of FIT,serum CA125 and ALP in the two groups were compared,and the relationship between the positive rates of FIT,serum CA125 and ALP in the observation group and the different pathological char-acteristics was analyzed.The ROC curve was drawn to analyze the efficacy of the three indicators in the di-agnosis of colorectal cancer.Results The positive rates of FIT,serum CA125 and ALP in the observa-tion group were 100.00％,98.39％and 96.77％,respectively,which were higher than those in the control group(P＜0.05).The higher the clinical stage of colorectal cancer,the larger the tumor diameter,and the higher the positive rates of FIT,serum CA125 and ALP in patients with liver metastasis(P＜0.05).There was no significant difference in the positive rates of different tumor types(P＞0.05).There was no significant difference in the positive rate of FIT,serum CA125 and ALP between patients with tumor loca-ted in the rectum and patients with tumor located in the left or right hemicolon(P＞0.05).ROC curve a-nalysis showed that the AUC of combined FIT,serum CA125 and ALP in diagnosis of colorectal cancer was 0.840,higher than that of single diagnosis,with a sensitivity of 98.4％and a specificity of 68.0％.Conclusion The expression levels of FIT,serum CA125 and ALP in colorectal cancer patients are higher,and the combined diagnosis of colorectal cancer has better efficacy and higher clinical value.
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