Correlation of Intestinal Mucosal Barrier Function with Th17/Treg Ratio and Leptin Level in Peripheral Blood of Patients with Ulcerative Colitis
Objective To study the correlation between intestinal mucosal barrier function with Th17/Treg ratio and leptin level in peripheral blood of patients with ulcerative colitis(UC).Methods Total 88 patients with UC admitted to our hospital from January 2015 to December 2020 were selected as the re-search objects.According to the modified Truelove and Witts scores,the disease severity was divided into mild,moderate and severe UC groups.The urinary lactulose/mannitol(L/M)ratio,Th17/Treg ratio and leptin level in each group were compared.Spearman correlation analysis was used to analyze the correlation of L/M with Th17/Treg and leptin.The ROC curve was drawn to calculate the optimal cut-off value,sensi-tivity and specificity of Th17/Treg and leptin in predicting intestinal mucosal barrier dysfunction.Results The L/M,Th17/Treg ratios and leptin level in the severe UC group were significantly higher than those in the moderate UC group and the mild UC group,and the L/M,Th17/Treg ratios and leptin level in the moderate UC group were higher than those in the mild UC group,with statistically significant differences(P＜0.05).Th17/Treg ratio and leptin level were positively correlated with L/M ratio(r=0.791,0.661,P＜0.05).The cut-off values of Th17/Treg ratio and leptin for predicting moderate to severe in-testinal mucosal barrier dysfunction in UC patients were 3.17 and 8.90 ng/mL,respectively,with AUC(95％CI)of 0.933(0.881-0.986)and 0.903(0.843-0.964),sensitivity of 89.28％and 81.34％,and specificity of 81.34％and 83.47％.Conclusion The severity of intestinal mucosal barrier dysfunction in UC patients is positively correlated with Th17/Treg ratio and leptin level,and monitoring Th17/Treg rati-o and leptin level has high value in predicting the severity of intestinal mucosal barrier dysfunction in UC patients.
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