首页|结直肠癌组织中CDX-2、PMS2表达水平及对不同分期结直肠癌的诊断价值

结直肠癌组织中CDX-2、PMS2表达水平及对不同分期结直肠癌的诊断价值

Expression Levels of CDX-2 and PMS2 in Colorectal Cancer Tissues and Their Diagnostic Value in Different Stages of Colorectal Cancer

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  • NSTL
  • 万方数据
目的:探讨结直肠癌组织中尾型同源盒转录因子-2(CDX-2)、错配修复蛋白(PMS2)的表达水平及对不同分期结直肠癌的诊断价值.方法:选取 2019 年 1 月至 2024 年 1 月,本院收治的 90 例结直肠癌患者为观察组,同期 90 例良性结直肠肿瘤患者为对照组.将观察组患者依照TNM分期分为Ⅰ期组 21 例,Ⅱ期组 23 例,Ⅲ期组 28 例和Ⅳ期组 18 例.所有患者肿瘤组织均行免疫组化染色,检测CDX-2、PMS2 表达水平,采用 Spearman相关性分析法分析CDX-2、PMS2 与结直肠癌临床分期的相关性,并建立受试者工作特征(ROC)曲线,分析CDX-2、PMS2 对不同分期结直肠癌的诊断效能.结果:观察组CDX-2、PMS2 的阳性率明显高于对照组(P<0.05),结直肠癌Ⅰ期组 CDX-2、PMS2 阳性率明显低于Ⅱ期组、Ⅲ期组和Ⅳ期组(P<0.05).Spearman分析显示 CDX-2、PMS2 与结直肠癌临床分期呈正相关(P<0.05),CDX-2 对不同分期结直肠癌的诊断曲线下面积为 0.622,灵敏度、特异度为 61.00%和 53.00%,PMS2 对不同分期结直肠癌的诊断曲线下面积为 0.675,灵敏度、特异度为 65.00%和 57.00%,两者联合的曲线下面积为 0.832,诊断灵敏度与特异度均明显高于单一指标(P<0.05).结论:结直肠癌组织中CDX-2、PMS2 表达明显上调,且CDX-2、PMS2 均对不同分期的结直肠癌具有一定诊断价值,临床可将两者结合为结直肠癌临床分期的判断提供参考.
Objective To investigate the expression levels of CDX-2 and mismatch repair protein(PMS2)in colorectal cancer tissues and their diagnostic value in different stages of colorectal cancer.Methods Total 90 patients with colorectal cancer admitted to our hospital from January 2019 to January 2024 were selected as the observation group,and another 90 patients with benign colorectal tumors were selected as the control group during the same period.According to TNM stage,the observation group was divided into stage Ⅰ group(21 cases),stage Ⅱ group(23 cases),stage Ⅲ group(28 cases)and stage Ⅳ group(18 ca-ses).Immunohistochemical staining was performed on the tumor tissues of all patients to detect the ex-pression levels of CDX-2 and PMS2.Spearman correlation analysis was used to analyze the correlation be-tween CDX-2,PMS2 and the clinical stage of colorectal cancer,and receiver operating characteristic(ROC)curve was established to analyze the diagnostic efficacy of CDX-2 and PMS2 in different stages of colorectal cancer.Results The positive rate of CDX-2 and PMS2 in the observation group was significantly higher than that in the control group(P<0.05),and the positive rate of CDX-2 and PMS2 in colorectal cancer stage Ⅰ group was significantly lower than that in stage Ⅱ,Ⅲ and Ⅳ groups(P<0.05).Spearman anal-ysis showed that CDX-2 and PMS2 were positively correlated with the clinical stages of colorectal cancer(P<0.05).The area under the diagnostic curve of CDX-2 for different stages of colorectal cancer was 0.622,and the sensitivity and specificity were 61.00%and 53.00%.The diagnostic area under the curve of PMS2 for different stages of colorectal cancer was 0.675,the sensitivity and specificity were 65.00%and 57.00%,and the combined area under the curve was 0.832,and the diagnostic sensitivity and specificity were significantly higher than that of single index(P<0.05).Conclusion The expression levels of CDX-2 and PMS2 in colorectal cancer tissues are significantly up-regulated.CDX-2 and PMS2 are of certain diagnostic value for different stages of colorectal cancer,and the combination of both can provide references for the judgment of clinical stages of colorectal cancer.

Colorectal cancerMid-tail homeobox transcription factor-2Mismatch repair proteinClini-cal stageDiagnostic value

张娜娜、柴力佳、钟洁

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河南省驻马店市中心医院病理科(河南 驻马店 463000)

河南省驻马店市第一人民医院病理科(河南 驻马店 463000)

结直肠癌 中尾型同源盒转录因子-2 错配修复蛋白 临床分期 诊断价值

2024

中国肛肠病杂志
中华中医药学会肛肠分会 山东中医药学会

中国肛肠病杂志

影响因子：0.131
ISSN：1000-1174
年,卷(期)：2024.44(6)