Effect of Wenyang Tongbian Decoction on Intestinal Flora in Patients with Yang Deficiency Type of Slow Transit Constipation
Objective To investigate the effect of Wenyang Tongbian Decoction on intestinal flora in pa-tients with yang deficiency type of slow transit constipation(STC).Methods From May 2020 to May 2023,total 60 patients with yang deficiency type of STC admitted to our hospital were randomly divided in-to treatment group and control group,with 30 cases in each group.The control group was given oral treat-ment of Mosapride,while the treatment group was given oral treatment of Wenyang Tongbian Decoction.Clinical symptom score and efficacy were evaluated after 2 weeks of treatment,and stool samples of pa-tients were collected for 16 SrDNA high-throughput sequencing to observe the changes of intestinal flora before and after treatment.Results The improvement of clinical symptom score in the treatment group was more obvious than that in the control group(P<0.05),and the total effective rate was higher(P<0.05).There was no significant change in the composition of main intestinal flora in the two groups before and after treatment(P>0.05),and there was no significant increase of common beneficial bacteria or de-crease of harmful bacteria in the fecal bacteria of the treatment group after treatment.Conclusion Wen-yang Tongbian Decoction is effective in treating yang deficiency type of slow transit constipation,but its mechanism has no obvious relationship with the regulation of intestinal flora.
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