Efficacy of Probiotics Combined with Trimebutine in Treatment of Diarrhea-Predominant Irritable Bowel Syn-drome and Its Effect on Interleukin-8,Interleukin-10,Interferon-γ,and 5-Hydroxytryptamine
Objective To investigate the clinical efficacy of probiotics combined with trimebutine in the treatment of diarrhea-predominant irritable bowel syndrome(IBS-D)and the effect on interleukin-8(IL-8),interleukin-10(IL-10),interferon-γ(IFN-γ)and 5-hydroxytryptamine(5-HT).Methods Total 80 patients with IBS-D admitted to our hospital from January 2021 to January 2023 were selected and divided into observation group and control group according to numerical random table method,with 40 cases in each group.The observation group was given oral probiotics combined with trimebutine,while the control group was given oral trimebutine only.The clinical efficacy,levels of IL-8,IL-10,IFN-γand 5-HT and ad-verse reactions were compared between the two groups.Results After treatment,the total effective rate was 90.0%in the observation group,which was significantly higher than 72.5%in the control group(P<0.05).The levels of IL-8,IFN-γand 5-HT in both groups were decreased,and the levels of IL-10 were increased.The indexes in the observation group were better than those in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Probiotics combined with trimebutin have significant clinical efficacy in the treatment of IBS-D and can significantly improve the levels of IL-8,IL-10,IFN-γand 5-HT,with mild adverse reactions,which is wor-thy of clinical promotion.
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