目的:研究地佐辛复合羟考酮对结直肠癌患者行腹腔镜辅助术(LAS)术后镇痛及对血清补体、前列腺素E2(PGE2)水平的影响。方法:回顾性分析我院2021年10月至2023年10月收治的106例行LAS结肠癌患者的临床资料，采用奇偶数字表法分为对照组和观察组，每组53例。对照组患者采用地佐辛治疗，观察组患者采用地佐辛复合羟考酮治疗，比较2组患者术后不同时点疼痛程度，手术前后血清补体状况、血清PGE2水平变化、免疫细胞含量水平变化以及术后用药的不良反应。结果:观察组患者术后6 h、12 h、24 h疼痛评分均低于对照组(P＜0。05)。术前2组患者血清补体水平比较差异无统计学意义(P＞0。05);术后2组患者血清补体水平均下降(P＜0。05)，但观察组患者C3、C4补体水平高于对照组(P＜0。05)。术前2组患者PGE2水平比较差异无统计学意义(P＞0。05);术后24 h 2组患者PGE2水平均降低(P＜0。05)，且观察组低于对照组(P＜0。05)。术前2组患者免疫细胞水平比较差异无统计学意义(P＞0。05);术后24 h 2组患者免疫细胞水平均下降(P＜0。05)，但观察组患者CD3、CD4+和NK细胞含量水平均高于对照组(P＜0。05)，CD4+/CD8+比值大于对照组(P＜0。05)。观察组患者用药不良反应发生率低于对照组(P＜0。05)。结论:对行LAS结肠癌患者应用地佐辛复合羟考酮可减轻患者术后疼痛，对患者血清补体水平影响小，具有免疫功能保护作用，有利于患者康复，且安全性更高。
Effect of Dezocine Combined with Oxycodone on Pain Relief and Serum Levels of Complement and PGE 2 in Colorectal Cancer Patients after Laparoscopic Assisted Surgery
Objective To study the effect of dezocine combined with oxycodone on pain relief and serum levels of complement and prostaglandin E2(PGE2)in colorectal cancer patients undergoing laparoscopic assisted surgery(LAS).Methods The clinical data of total 106 colon cancer patients undergoing LAS admitted to our hospital from October 2021 to October 2023 were retrospectively analyzed and divided into control group and observation group by odd-even number table method,with 53 cases in each group.The control group was treated with dezocine,while the observation group was treated with dezocine combined with oxycodone.The pain degree,serum levels of complement and PGE2,immune cell content and postop-erative adverse reactions of the two groups were compared at different time points after surgery.Results The pain scores of the observation group at 6 h,12 h and 24 h after surgery were lower than those of the control group(P＜0.05).There was no significant difference in serum levels of complement between the two groups before surgery(P＞0.05).After surgery,the serum levels of complement in both groups were decreased(P＜0.05),but the complement levels of C3 and C4 in the observation group were higher than those in the control group(P＜0.05).There was no significant difference in PGE2 level between the two groups before surgery(P＞0.05).The level of PGE2 in both groups was decreased 24 h after surgery(P＜0.05),which was lower in the observation group than in the control group(P＜0.05).There was no significant difference in the levels of immune cells between the two groups before surgery(P＞0.05).The levels of immune cells in both groups were decreased(P＜0.05)24 h after operation,but the contents of CD3,CD4+and NK cells were higher in the observation group than in the control group(P＜0.05),and the ratio of CD4+/CD8 in the observation group was higher than that in the control group(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).Conclusion The application of dezocine combined with oxycodone in colon cancer patients under-going LAS can alleviate postoperative pain,have little effect on serum complement levels,have a protec-tive effect on immune function,which is conducive to the rehabilitation of patients,with higher safety.
NETL
NSTL
万方数据
