Medication Regularity of Chinese Medicinal Retention Enema in Treating Chronic Proctitis Based on Data Mining
Objective To analyze the medication regularity of Chinese medicinal retention enema in the treatment of chronic proctitis by means of data mining technology.Methods By searching,collecting and sorting out the journal literature of Chinese medicinal retention enema in the treatment of chronic proc-titis in the medical database of CNKI,Wanfang and VIP from the establishment to December 31,2023,the literature of clinical case observation was screened out,and the database of Chinese medicinal enema formulas was established using Excel(2021).Statistical analysis was carried out on the number of cases involved in the included literature,as well as the drug frequency,property,flavor and channel tropism,etc.IBM SPSS Modeler 18.0 and IBM SPSS Statistics 26 were used to conduct multi-dimensional analysis of high-frequency drugs such as cluster analysis,association rules and complex networks.Results A to-tal of 181 literatures related to the subject were searched and 58 effective enema formulas were selected af-ter reading one by one,with a total of 115 drugs and a total frequency of 512.Among them,24 drugs were high-frequency drugs(frequency ≥7),and the top 7 drugs were Huanglian(Coptidis Rhizoma),Diyu(Sanguisorbae Radix),Baiji(Bletillae Rhizoma),Baijiangcao(Patrinia Herba),Huangbo(Phellodendri Chinensis Cortex),Danggui(Angelicae Sinensis Radix)and Huangqin(Scutellariae Radix).The medici-nal property was mainly cold,warm or neutral.The medicinal flavor was mainly bitter,sweet or acrid.The channel tropism was mainly liver or lung channel,followed by spleen,stomach,large intestine or heart channel,with the main effect of clearing heat,draining dampness,removing toxin,regulating qi and eliminating stagnation.The top 5 frequently used medicinal pairs were Huanglian-Huangqin,Diyu-Bai-jiangcao,Diyu-Baiji,Huanglian-Huangbo,and Diyu-Huaihua(Sophorae Flos),and five core medicinal combinations were obtained by cluster analysis.Conclusion Retention enema formulas in the treatment of chronic proctitis mostly use both cold and warm drugs,acridity opening and bitter discharging as the method,treat with both tonifying and purging,and regulate liver,spleen,lung and stomach.Drugs for warming yang,draining dampness,clearing heat,drying dampness,purging fire,removing toxin,cooling blood,stop bleeding,regulating qi and invigorating spleen are mainly used.
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