Correlation Analysis of Serum Inflammatory Factors and Erythrocyte Immune Indexes with Dehydration Degree in Children with Rotavirus Enteritis
Objective To analyze the correlation between serum inflammatory factors and erythrocyte immune indexes with the dehydration degree in children with rotavirus enteritis.Methods Total 70 chil-dren with rotavirus enteritis admitted to our department from January 2023 to February 2024 and 70 healthy children(control group)who underwent physical examination during the same period were select-ed as the study objects.Children with rotavirus enteritis were further divided into mild,moderate and se-vere dehydration groups according to the degree of dehydration.The levels of serum inflammatory factors of tumor necrosis factor α(TNF-α),procalcitonin(PCT)and hypersensitive C-reactive protein(hs-CRP),and the levels of erythrocyte immune indexes of RFER,ERPN,FEIR,RBC-C3bR and RBC-ICR were detec-ted,and the correlation between the above indexes and the degree of dehydration were analyzed.Results The levels of serum inflammatory factors of TNF-α,PCT and hs-CRP in children with rotavirus enteritis were higher than those in the control group,and the levels of RFER,ERPN and RBC-C3bR in the erythro-cyte immune ndexes were lower than those in the control group,while the levels of FEIR and RBC-ICR were higher than those in the control group(P＜0.05).With the aggravation of dehydration,the serum levels of TNF-α,PCT,hs-CRP,FEIR and RBC-ICR in children with rotavirus enteritis were increased suc-cessively,while the levels of RFER,ERPN and RBC-C3bR were decreased successively,and there were sta-tistically significant differences in the above indexes among the groups without dehydration and those with mild,moderate and severe dehydration(P＜0.05).Spearman correlation analysis showed that the serum levels of TNF-α,PCT and hs-CRP were negatively correlated with the levels of RFER,ERPN and RBC-C3bR in children with rotavirus enteritis(P＜0.05),but positively correlated with the levels of FEIR and RBC-ICR(P＜0.05).Conclusion Serum inflammatory factors of TNF-α,PCT,hs-CRP,and erythro-cyte immune indexes of RFER,ERPN,FEIR,RBC-C3bR,and RBC-ICR are closely related to the dehydra-tion degree in children with rotavirus enteritis,and can be used as reference indexes to evaluate the degree of dehydration.
Rotavirus enteritisInflammatory factorsErythrocyte immunityDegree of dehydrationCorrelation
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