双歧杆菌乳杆菌三联活菌片联合水溶性膳食纤维预防老年抗生素相关性腹泻的临床效果
Clinical Effect of Bifidobacterium and Lactobacillus Triple Viable Tablets Combined with Water-Soluble Dietary Fiber in Prevention of Senile Antibiotic-Related Diarrhea
汤金金 1张巧云 1范明明1
作者信息
- 1. 南阳市第一人民医院消化内科(河南南阳 473000)
- 折叠
摘要
目的:探讨双歧杆菌乳杆菌三联活菌片联合水溶性膳食纤维预防老年抗生素相关性腹泻的临床效果.方法:将2023年3月至2024年2月于我院接受抗生素治疗的70例老年患者按1:1随机分配至试验组和对照组,各35例.试验组予双歧杆菌乳杆菌三联活菌片联合水溶性膳食纤维干预,对照组予麦芽糊精进行对照.比较2组患者抗生素相关性腹泻发生率、腹泻病程、粪便培养结果及不良反应发生情况.结果:试验组抗生素相关性腹泻发生率(8.57％)明显低于对照组(34.29％),腹泻病程[(3.12±0.45)d]短于对照组[(5.35±0.35)d],不良反应发生率(8.57％)明显低于对照组(34.29％),P＜0.05.干预第3天、第7天、第14天,试验组患者肠道双歧杆菌和乳酸杆菌计数逐渐增加,P＜0.05.结论:双歧杆菌乳杆菌三联活菌片联合水溶性膳食纤维预防老年抗生素相关性腹泻确有疗效,不仅可降低腹泻发生率,缩短腹泻病程,减少不良反应,而且可调节肠道菌群.
Abstract
Objective To investigate the clinical effect of bifidobacterium and lactobacillus triple viable tablets combined with water-soluble dietary fiber in the prevention of senile antibiotic-related diarrhea.Methods Total 70 senile patients who received antibiotics in our hospital from March 2023 to February 2024 were randomly assigned to experimental group and control group according to 1:1,with 35 cases in each group.The experimental group was treated with bifidobacteria and lactobacillus triple viable tablets combined with water-soluble dietary fiber,and the control group was given maltodextrin to be compared.The incidence of antibiotic-associated diarrhea,the course of diarrhea,the results of fecal culture and the in-cidence of adverse reactions were compared between the two groups.Results The incidence of antibiotic-associated diarrhea in the experimental group(8.57％)was significantly lower than that in the control group(34.29％).The duration of diarrhea[(3.12+0.45)d]was shorter than that in the control group[(5.35+0.35)d],and the incidence of adverse reactions(8.57％)was significantly lower than that in the control group(34.29％)(P＜0.05).On the 3rd,7th and 14th day of intervention,the counts of intestinal bifidobacterium and lactobacillus in the experimental group gradually increased(P＜0.05).Conclusion Bifidobacterium and lactobacillus triple viable tablets combined with water-soluble dietary fiber is effec-tive in preventing senile antibiotic-related diarrhea,which can not only reduce the incidence of diarrhea,shorten the course of diarrhea,decrease adverse reactions,but also regulate intestinal flora.
关键词
抗生素相关性腹泻/老年人/双歧杆菌乳杆菌三联活菌片/水溶性膳食纤维/预防Key words
Antibiotic-related diarrhea/The elderly/Bifidobacterium and lactobacillus triple viable tab-lets/Water-soluble dietary fiber/Prevention引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据