首页|3D Photo-Fabrication for Tissue Engineering and Drug Delivery

3D Photo-Fabrication for Tissue Engineering and Drug Delivery

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The most promising strategies in tissue engineering involve the integration of a triad of biomaterials,living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration.To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix (ECM) on a cellular and subcellular scale.Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer.Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs.Recently, photofabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds.This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications.State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors.Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs.This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.

3D photo-fabricationbiomaterialstissue engineeringdrug delivery

Rúben F.Pereira、Paulo J.Bártolo

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Centre for Rapid and Sustainable Product Development (CDRsp), Polytechnic Institute of Leiria, Marinha Grande 2430-028, Portugal

Instituto de Investiga(a)(a)o e Inova(c)(a)o em Saúde (13S), Universidade do Porto, Porto 4200-393, Portugal

Instituto Nacional de Engenharia Biomédica (INEB), Universidade do Porto, Porto 4150-180,Portugal

Instituto de Ci(e)ncias Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto 4050-313, Portugal

School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Manchester M13 9PL, UK

Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK

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authors thank the support of the Portuguese Foundation for Science and Technology (FCT) through the strategic projectRuben F.Pereira is grateful to the FCT for the doctoral

UID/Multi/04044/2013SFRH/BD/91151/2012

2015

10.15302/J-ENG-2015015

工程科学(英文版)
中国工程院出版委员会

工程科学(英文版)

影响因子：0.226
ISSN：1672-4178
年,卷(期)：2015.1(1)
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