首页|Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device
Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device
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Convection-enhanced delivery (CED) is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces.We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms.Infusions of dye were conducted in 0.6％ (w/w) agarose tissue phantoms with isothermal conditions at 15 ℃, 20 ℃, 25 ℃, and 30 ℃.Infusion metrics were quantified using a custom shadowgraphy setup and imageprocessing algorithm.These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature.A second set of proofof-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion.The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30 ℃ showing a 7-fold increase at 100 min over the 15 ℃ isothermal case.Infusions during photothermal heating (1064 nm at 500 mW) showed a similar effect with a 3.5-fold increase at 4 h over the control (0 mW).These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.
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