首页|Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions

Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions

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The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35 years.Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging.For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored.However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded.In part, this is due to advances in MRI instrumentation, 19F/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners.These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of 19F into early clinical evaluation.In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.

fluorinemagnetic resonance imaging (MRI)dual-tuned coilperfluorocarbonangiogenesiscell labeling

Anne H.Schmieder、Shelton D.Caruthers、Jochen Keupp、Samuel A.Wickline、Gregory M.Lanza

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Division of Cardiology, Washington University School of Medical, St.Louis, MO 63110, USA

Toshiba Medical Research Institute USA, Inc., Cleveland, OH 44143, USA

Department of Biomedical Engineering, Washington University, St.Louis, MO 63130, USA

Philips Research Hamburg, Hamburg 22335, Germany

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This research was supported in whole or part by grants from the National Institutes of HealthThis research was supported in whole or part by grants from the National Institutes of HealthThis research was supported in whole or part by grants from the National Institutes of HealthThis research was supported in whole or part by grants from the National Institutes of HealthThis research was supported in whole or part by grants from the National Institutes of Health

CA154737CA199092HL122471HL112518HL113392

2015

10.15302/J-ENG-2015103

工程科学(英文版)
中国工程院出版委员会

工程科学(英文版)

影响因子：0.226
ISSN：1672-4178
年,卷(期)：2015.1(4)
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