首页|Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease:current knowledge and new insights

Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease:current knowledge and new insights

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Phenylacetylglutamine(PAGln)is an amino acid derivate that comes from the amino acid phenylalanine.There are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular diseases.In this review,we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of PAGln.We summarized the epidemiological evidence to show the role of PAGln in diagnostic and prognostic value in several cardiovascular diseases,such as heart failure,coronary heart disease/atherosclerosis,and cardiac arrhythmia.The underlying mechanism of PAGln is now considered to be related to the thrombotic potential of platelets via adrenergic receptors.Besides,other possible mechanisms such as inflammatory response and oxidative stress could also be induced by PAGln.Moreover,since PAGln is produced across different organs including the intestine,liver,and kidney,the cross-talk among multiple organs focused on the function of this uremic toxic metabolite.Finally,the prognostic value of PAGln compared to the classical biomarker was discussed and we also highlighted important gaps in knowledge and areas requiring future investigation of PAGln in cardiovascular diseases.

PAGlncardiovascular diseasegut microbiotauremic metabolitebiomarker

Yaonan Song、Haoran Wei、Zhitong Zhou、Huiqing Wang、Weijian Hang、Junfang Wu、Dao Wen Wang

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Division of Cardiology,Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Wuhan 430030,China

国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Hubei Provincial Key Research and Developmental ProgramHubei Provincial Natural Science Foundation of ChinaHubei Provincial Natural Science Foundation of China

2022YFC34007003197135882370397U22A20266821004022022BCA0372017CFB5362022CFB201

2024

10.1007/s11684-024-1055-9

医学前沿
高等教育出版社

医学前沿

CSTPCD
影响因子：1.362
ISSN：2095-0217
年,卷(期)：2024.18(1)
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