首页|Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture
Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture
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Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323 community-dwelling subjects aged ≥40 years from China.Early-life famine exposure was identified based on the participants'birth dates.General obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of 40 typically caused by falls from standing height or lower.Compared to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95％confidence intervals(CIs)of 3.55(1.57-8.05),3.90(1.57-9.71),and 3.53(1.05-11.88),respectively,but not in men.Significant interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95％CI:3.32,1.17-9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.
famineobesitybody mass indexwaist-to-hip ratiolow-energy fracture
Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People's Republic of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shangh
Ministry of Science and Technology of China国家自然科学基金国家自然科学基金Shanghai Outstanding Academic Leaders PlanShanghai Medical and Health Development FoundationClinical Research Plan of SHDCScience and Technology Committee of ShanghaiKey Medical Subject of Jiading District,Shanghai
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