Unraveling the complex roles of macrophages in obese adipose tissue:an overview

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外文摘要：Macrophages,a heterogeneous population of innate immune cells,exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic diseases.The activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects,inducing insulin resistance through increased inflammation,impaired thermogenesis,and adipose tissue fibrosis.Meanwhile,adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis,facilitating the clearance of dead adipocytes,and promoting mitochondrial transfer.Exploring the heterogeneity of macrophages in obese adipose tissue is crucial for unraveling the pathogenesis of obesity and holds significant potential for targeted therapeutic interventions.Recently,the dual effects and some potential regulatory mechanisms of macrophages in adipose tissue have been elucidated using single-cell technology.In this review,we present a comprehensive overview of the intricate activation mechanisms and diverse functions of macrophages in adipose tissue during obesity,as well as explore the potential of drug delivery systems targeting macrophages,aiming to enhance the understanding of current regulatory mechanisms that may be potentially targeted for treating obesity or metabolic diseases.

外文关键词：

obesityinflammationadipose tissue macrophagesadipose tissue homeostasis

作者：

Chang Peng、Jun Chen、Rui Wu、Haowen Jiang、Jia Li

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作者单位：

State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

University of Chinese Academy of Sciences,Beijing 100049,China

Department of Prosthodontics,Shanghai Engineering Research Center of Advanced Dental Technology and Materials,Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310000,China

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基金：

国家自然科学基金Shanghai Municipal Science and Technology Major ProjectLingang Laboratory

项目编号：

32000525TM202101H001LG202103-03-01

出版年：

2024

DOI：

10.1007/s11684-023-1033-7

医学前沿

高等教育出版社

医学前沿

CSTPCD

影响因子：1.362

ISSN：2095-0217

年,卷(期)：2024.18(2)

参考文献量298