首页|Pathological progression of osteoarthritis:a perspective on subchondral bone

Pathological progression of osteoarthritis:a perspective on subchondral bone

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Osteoarthritis(OA)is a degenerative bone disease associated with aging.The rising global aging population has led to a surge in OA cases,thereby imposing a significant socioeconomic burden.Researchers have been keenly investigating the mechanisms underlying OA.Previous studies have suggested that the disease starts with synovial inflammation and hyperplasia,advancing toward cartilage degradation.Ultimately,subchondral-bone collapse,sclerosis,and osteophyte formation occur.This progression is deemed as"top to bottom."However,recent research is challenging this perspective by indicating that initial changes occur in subchondral bone,precipitating cartilage breakdown.In this review,we elucidate the epidemiology of OA and present an in-depth overview of the subchondral bone's physiological state,functions,and the varied pathological shifts during OA progression.We also introduce the role of multifunctional signal pathways(including osteoprotegerin(OPG)/receptor activator of nuclear factor-kappa B ligand(RANKL)/receptor activator of nuclear factor-kappa B(RANK),and chemokine(CXC motif)ligand 12(CXCL12)/CXC motif chemokine receptor 4(CXCR4))in the pathology of subchondral bone and their role in the"bottom-up"progression of OA.Using vivid pattern maps and clinical images,this review highlights the crucial role of subchondral bone in driving OA progression,illuminating its interplay with the condition.

osteoarthritissubchondral boneOPG/RANKL/RANKCXCL12/CXCR4

Xuefei Li、Wenhua Chen、Dan Liu、Pinghua Chen、Shiyun Wang、Fangfang Li、Qian Chen、Shunyi Lv、Fangyu Li、Chen Chen、Suxia Guo、Weina Yuan、Pan Li、Zhijun Hu

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Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China

Research and Development Center of Chinese Medicine Resources and Biotechnology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

Traditional Chinese Medicine Rehabilitation Service Capability Enhancement ProjectThreeyear Action Plan for Shanghai to Further Accelerate the Inheritance,Innovation and Development of Traditional Chinese MPudong New Area Health System Pudong Famous Traditional Chinese Medicine Training Plan

Medical 032ZY2021-2023-0201-01PWRzm2020-15

2024

10.1007/s11684-024-1061-y

医学前沿
高等教育出版社

医学前沿

CSTPCD
影响因子：1.362
ISSN：2095-0217
年,卷(期)：2024.18(2)
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