首页|Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

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Exosome therapy holds great promise as a novel approach to improve acute skin wound healing.This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond.Exosomes,small extracellular vesicles secreted by various stem cells,have emerged as potent mediators of intercellular communication and tissue repair.One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy,such as immune rejection or stem cells differentiating into unwanted cell types.However,further research is necessary to optimize exosome therapy,not only in the areas of exosome isolation,characterization,and engineering,but also in determining the optimal dose,timing,administration,and frequency of exosome therapy.Thus,optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer,ischemia,or inflammation.This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

exosomesstem cellstherapeutic impactskinwound healing

Tianjing Sun、Mo Li、Qi Liu、Anyong Yu、Kun Cheng、Jianxing Ma、Sean Murphy、Patrick Michael McNutt、Yuanyuan Zhang

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Department of Emergency,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China

Department of Nephrology,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China

Division of Pharmacology and Pharmaceutical Sciences,School of Pharmacy,University of Missouri-Kansas City,Kansas City,MO 64108,USA

Department of Biochemistry,Wake Forest University School of Medicine,Winston-Salem,NC 27157,USA

Wake Forest Institute of Regenerative Medicine,Wake Forest School of Medicine,Winston-Salem,NC 27109,USA

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国家自然科学基金国家自然科学基金Federal funds from the National Institute of Allergy and Infectious Diseases,National Institutes of HealthFederal funds from the National Institute of Allergy and Infectious Diseases,National Institutes of Health

8206024582260254R21 AI152832R03 AI165170

2024

10.1007/s11684-023-1031-9

医学前沿
高等教育出版社

医学前沿

CSTPCD
影响因子：1.362
ISSN：2095-0217
年,卷(期)：2024.18(2)
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