首页|Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
The treatment of PML/RARA+acute promyelocytic leukemia(APL)with all-trans-retinoic acid and arsenic trioxide(ATRA/ATO)has been recognized as a model for translational medicine research.Though an altered microenvironment is a general cancer hallmark,how APL blasts shape their plasma composition is poorly understood.Here,we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters,proteomes,and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction therapy.Our study revealed the two prominent features of the APL plasma,suggesting a possible involvement of APL blasts in modulating plasma composition.One was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts,and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA.Furthermore,results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage,which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins.Overall,our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.

acute promyelocytic leukemiaplasma proteomicsplasma metabolomicscross-sectional correlation networkpathogenesistreatment

Niu Qiao、Yizhu Lyu、Feng Liu、Yuliang Zhang、Xiaolin Ma、Xiaojing Lin、Junyu Wang、Yinyin Xie、Ruihong Zhang、Jing Qiao、Hongming Zhu、Li Chen、Hai Fang、Tong Yin、Zhu Chen、Qiang Tian、Saijuan Chen

展开 >

Shanghai Institute of Hematology,State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine at Shanghai,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Department of Hematology,Second Hospital of Dalian Medical University,Dalian 116021,China

State Key Laboratory of Medical Genomics,the Double First-Class Project教育部项目Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell ResearchOverseas Expertise Introduction Project for Discipline InnovationOverseas Expertise Introduction Project for Discipline Innovation国家自然科学基金国家自然科学基金Shanghai Clinical Research Center for Hematological diseaseShanghai Shenkang Hospital Development CenterShanghai Major Project for Clinical MedicineYangfan Program of the Science and Technology Commission of Shanghai MunicipalityShanghai Institute of HematologyNational Research Center for Translational Medicine at Shanghai

WF5101626022019CXJQ01111 ProjectB17029822300063217066319MC1910700SHDC2020CR50022017ZZ0100222YF1425500

2024

10.1007/s11684-023-1022-x

医学前沿
高等教育出版社

医学前沿

CSTPCD
影响因子：1.362
ISSN：2095-0217
年,卷(期)：2024.18(2)
  • 53