首页|Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

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ALKBH5 is a master regulator of N6-methyladenosine(m6A)modification,which plays a crucial role in many biological processes.Here,we show that ALKBH5 is required for breast tumor growth.Interestingly,PRMT6 directly methylates ALKBH5 at R283,which subsequently promotes breast tumor growth.Furthermore,arginine methylation of ALKBH5 by PRMT6 increases LDHA RNA stability via m6A demethylation,leading to increased aerobic glycolysis.Moreover,PRMT6-mediated ALKBH5 arginine methylation is confirmed in PRMT6-knockout mice.Collectively,these findings identify a PRMT6-ALKBH5-LDHA signaling axis as a novel target for the treatment of breast cancer.

PRMT6ALKBH5N6-methyladenosineglycolysistumor growth

Xue Han、Chune Ren、Aifang Jiang、Yonghong Sun、Jiayi Lu、Xi Ling、Chao Lu、Zhenhai Yu

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Department of Reproductive Medicine,Affiliated Hospital of Weifang Medical University,Weifang 261053,China

Department of Pathology,Affiliated Hospital of Weifang Medical University,Weifang 261053,China

国家自然科学基金国家自然科学基金山东省自然科学基金山东省自然科学基金Shandong Province College Science and Technology Plan Projectmedical and health technology development program in Shandong Province

8197248982003201ZR2020YQ58ZR2020QH255J17KA2542018WS057

2024

10.1007/s11684-023-1028-4

医学前沿
高等教育出版社

医学前沿

CSTPCD
影响因子：1.362
ISSN：2095-0217
年,卷(期)：2024.18(2)
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