Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

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外文摘要：Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progression.A tumor subpopulation called liver cancer stem cells(CSCs)significantly accounts for the initiation,metastasis,therapeutic resistance,and recurrence of liver cancer.Emerging evidence demonstrates that the interaction between liver CSCs and immune cells plays a crucial role in shaping an immunosuppressive microenvironment and determining immunotherapy responses.This review sheds light on the bidirectional crosstalk between liver CSCs and immune cells for liver cancer progression,as well as the underlying molecular mechanisms after presenting an overview of liver CSCs characteristic and their microenvironment.Finally,we discuss the potential application of liver CSCs-targeted immunotherapy for liver cancer treatment.

外文关键词：

liver cancercancer stem cellimmune cellimmunotherapy

作者：

Yue Ma、Hongwei Lv、Fuxue Xing、Wei Xiang、Zixin Wu、Qiyu Feng、Hongyang Wang、Wen Yang

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作者单位：

Cancer Research Center,First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230027,China

National Center for Liver Cancer,Naval Medical University(Second Military Medical University),Shanghai 201805,China

International Co-operation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Hospital,Naval Medical University(Second Military Medical University),Shanghai 200438,China

Shanghai Key Laboratory of Hepato-biliary Tumor Biol

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChinese National Key ProjectShanghai Municipal Commission of Education ProjectProgram of Shanghai Academic Research Leader

项目编号：

82273176819028948197277981903036816220398183005491859205819881012018ZX10723204-006-003201901070007E0006523XD1404800

出版年：

2024

DOI：

10.1007/s11684-023-1049-z

医学前沿

高等教育出版社

医学前沿

CSTPCD

影响因子：1.362

ISSN：2095-0217

年,卷(期)：2024.18(3)