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Intracellular checkpoints for NK cell cancer immunotherapy

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Intracellular checkpoints for NK cell cancer immunotherapy
Natural killer(NK)cells are key innate immune lymphocytes,which play important roles against tumors.However,tumor-infiltrating NK cells are always hypofunctional/exhaustive.On the one hand,this state is contributed by context-dependent interactions between inhibitory NK cell checkpoint receptors and their ligands,which usually vary in different tumor types and stages during tumor development.On the other hand,the inhibitory functions of intracellular checkpoint molecules of NK cells are more similar across different tumor types,representing common mechanisms limiting the potential of NK cell therapy.In this review,representative NK cell intracellular checkpoint molecules in different aspects of NK cell biology were reviewed,and therapeutic potentials were discussed by targeting these molecules to promote antitumor NK cell therapy.

genomic editingNK cell exhaustionimmune checkpointinhibitory moleculesimmune tolerance

Yingying Huang、Zhigang Tian、Jiacheng Bi

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CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

Department of Urology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China

Center for Genomic and Personalized Medicine,Guangxi Medical University,Nanning 530021,China

Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine,Nanning 530021,China

Guangxi Key Laboratory for Gen

The CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Basic Medical Sciences,Division of Life Sciences and Medicine University of Science and Technology of China,Hefei 230027,China

Institute of Immunology,University of Science and Technology of China,Hefei 230027,China

Research Unit of NK Cell Study,Chines

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genomic editing NK cell exhaustion immune checkpoint inhibitory molecules immune tolerance

2024

10.1007/s11684-024-1090-6

医学前沿
高等教育出版社

医学前沿

CSTPCD
影响因子：1.362
ISSN：2095-0217
年,卷(期)：2024.18(5)