首页|Preparation and in vitro cytotoxicity study of poly (aspartic acid) stabilized magnetic nanoparticles
Preparation and in vitro cytotoxicity study of poly (aspartic acid) stabilized magnetic nanoparticles
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Biocompatible magnetic nanoparticles were prepared by co-precipitation method in the presence of poly (aspartic acid) (PAsp) as stabilizer, which was one of the most extensively studied and used poly(amino acids). As a biocompatible dispersant, PAsp was successfully attached to the Fe3O4 nanoparticles, which was approved by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA). From X-ray diffraction (XRD) and vibrating sample magnetometry (VSM) measurement results, it was found that PAsp stabilized iron oxide nanoparticles possess excellent Fe3O4 crystal structure and superparamagnetic property. Compared with trisodium citrate stabilized magnetic nanoparticles, PAsp stabilized magnetic nanoparticles were biocompatible and with lower cytotoxicity, which makes it more applicable in medicine, biology and biomaterial science.
Key Laboratory of Molecular Engineering of Polymers (Ministry of Education), Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China
国家自然科学基金国家自然科学基金国家自然科学基金Shanghai Committee of Science and Technology,China
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