Abstract
BACKGROUND:The present study elucidates the protective potential of bromelain against dichlorvos intoxication in mice brains.Dichlorvos induces the oxidative stress by disproportionating the balance between free radicals generation and their scavenging in neurons which leads to neuronal degeneration.METHODS:In this study,mice were divided into four groups-group Ⅰ (control),group Ⅱ (dichlorvos treated),group Ⅲ (bromelain treated) and group Ⅳ (exposed to both bromelain and dichlorvos both).RESULTS:Dichlorvos treatment increased the levels of thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC) which indicate the increased oxidative stress.Meanwhile,brain endogenous antioxidants and cholinesterases level was decreased after dichlorvos exposure.Levels of TBARS and PCC decreased whereas cholinesterases level was recorded to be elevated after bromelain exposure.CONCLUSION:Bromelain offered neuroprotection by decreasing oxidative stress and augmenting cholinesterases in mice brains.This study highlights the invulnerability of bromelain against oxidative and cholinergic deficits in mice brains.
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维普
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