首页|Metastatic tumor cells-genotypes and phenotypes

Metastatic tumor cells-genotypes and phenotypes

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BACKGROUND:Metastasis is the primary cause of mortality in cancer patients.Therefore,elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research.OBJECTIVE:To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells.METHOD and RESULT:In-depth genetic analysis of tumor cells,especially with advances in the next-generation sequencing,have revealed insights of the genotypes of metastatic tumor cells.Also,studies have shown that the cancer stem cell (CSC) and epithelial to mesenchymal transition (EMT) phenotypes are associated with the metastatic cascade.CONCLUSION:In this review,we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.

metastasisepithelial to mesenchymal transition (EMT)cancer stem cellcirculating tumor cellscellular plasticityphenotype dynamics

Dingcheng Gao、Vivek Mittal、Yi Ban、Ana Rita Lourenco、Shira Yomtoubian、Sharrell Lee

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Department of Cardiothoracic Surgery, Department of Cell and Developmental Biology, Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY10065, USA

2018

生物学前沿
高等教育出版社

生物学前沿

影响因子：0.2
ISSN：1674-7984
年,卷(期)：2018.13(4)
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