首页|Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature

Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature

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BACKGROUND:Diabetes mellitus (DM) is one of the most prevalent chronic diseases,and its prevalence continues to increase globally.The impact of mitochondrial dysfunction and lipid metabolism on diabetes mellitus and insulin resistance (IR) has been implicated in several previous reports;however,the results of studies are confusing despite four decades of study.METHODS/RESULTS:This review has evaluated updated understanding of the role of mitochondrial dysfunction and lipid metabolism on type 2 diabetes,and found that mitochondrial dysfunction and lipid metabolism disorder induce the dysregulation of liver and pancreatic beta cells,insulin resistance,and type 2 diabetes.CONCLUSION:Mitochondrial dysfunction and lipid metabolism induce metabolic dysregulation and finally increasing the possibility of diabetes.

Insulin resistanceType 2 diabetesMitochondrial dysfunctionLipid metabolism

Karimeh Haghani、Pouyan Asadi、Gholamreza Taheripak、Ali Noori-Zadeh、Shahram Darabi、Salar Bakhtiyari

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Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Department of Clinical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Department of Clinical Biochemistry, Faculty of Paramedicine, Ilam University of Medical Sciences, Ilam, Iran

Cellular and Molecular Research Center, Qazvin University of Medical Science, Qazvin, Iran

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2018

生物学前沿
高等教育出版社

生物学前沿

影响因子：0.2
ISSN：1674-7984
年,卷(期)：2018.13(6)
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