Classification on hazard of medium is one of the key factors to determine the classification,design,manufacture and inspection of pressure vessels.This paper first discusses the existing problems of classification on hazard of medium in TSG 21-2016 Supervision Regulation on Safety Technology for Stationary Pressure Vessel.The background of the newly promulgated national standard GB/T 42594-2023 Guidelines for Classification on Hazard of Medium in Pressure Equipment and the main classification methods of medium toxicity and explosives are introduced,and the changes of current medium groups according to TSG 21-2016 are further compared.The rationality of the new standard for classification on hazard of medium in pressure equipment is analyzed.And finally,it is suggested that quoting GB/T 42594-2023 as the reference standard of medium in the subsequent revision of TSG 21-2016.