水凝胶在周围神经损伤修复领域的应用研究进展
Progress on application of hydrogels in the field of peripheral nerve injury repair
秦春 1孔令同 2许硕贵2
作者信息
- 1. 海军军医大学研究生院,上海 200433
- 2. 海军军医大学附属长海医院创伤骨科,上海 200433
- 折叠
摘要
作为临床常见创伤性疾病之一,周围神经损伤(peripheral nerve injury,PIN)由于损伤后再生速度缓慢,常会引起神经疼痛、异常反射、自主神经紊乱等,甚至出现感觉运动障碍严重影响机体功能.即便作为治疗金标准,自体神经移植也存在供区有限、供体损伤等局限性,极大地限制了其临床应用效果.因此,制备适合临床实践的人工神经移植物成为PIN治疗的未来发展趋势,修复损伤缺损和促进神经再生也成为组织工程和再生医学的研究热点.近年来,对人工神经导管(nerve guidance conduits,NGCs)在神经再生修复领域进行了广泛研究,其中支架材料和内填充物作为神经导管的核心要素也成为研究的重点,新材料应用、包埋干细胞/前体细胞、开发负载营养因子及载药缓释系统均取得了一系列成果.本研究探讨了水凝胶及其相关衍生材料在PIN修复领域中的应用进展,为推动组织工程和临床医学的相关研究提供新的思路.
Abstract
As one of the common traumatic diseases in clinical practice,peripheral nerve injury(PIN)often causes nerve pain,abnormal reflexes,autonomic disorders,and even sensorimotor disorders due to the slow regeneration rate after injury,which seriously affects body function.Even as the gold standard of treatment,autologous nerve transplantation has limitations such as limited donor area and donor injury,which greatly limits its clinical application effect.Therefore,the preparation of ar-tificial nerve grafts suitable for clinical practice has become the future development trend of peripheral nerve injury treatment,and the repair of injury defects and the promotion of nerve regeneration have also become research hotspots in tissue engineer-ing and regenerative medicine.In recent years,extensive research has been carried out on nerve guidance conduits(NGCs)in the field of nerve regeneration and repair,in which scaffold materials and intemal fillers have also become the focus of research as the core elements of neural catheters,and a series of achievements have been made in the application of new materials,em-bedding stem cells/precursor cells,and developing trophic factors and drug-loaded sustained-release systems.Therefore,this paper focuses on the application progress of hydrogel and its related derivative materials in the field of peripheral nerve injury repair,and provides new ideas for promoting the related research of tissue engineering and clinical medicine.
关键词
水凝胶/周围神经损伤/人工神经导管Key words
Hydrogel/Peripheral nerve injury/Artificial nerve conduit引用本文复制引用
基金项目
国家自然科学基金青年科学基金项目(82302718)
出版年
2024
国家科技期刊平台
NSTL
万方数据