Tendon injuries are frequently encountered in clinical practice,and traditional repair methods rarely achieve complete restoration of the tendon's original structure and functionality.The challenges of accelerating and optimizing the heal-ing of injured tendons,enhancing the strength of the regenerated tendon,and preventing adhesion remain significant in clinical settings.Tendon tissue engineering,which combines material science,cell biology,and molecular biology,involves the syner-gistic application of multiple factors to create functional constructs and has become an emerging technique with promise for re-pair.The maximization of the regenerative potential of these elements is a critical research question.Future research should concentrate on discovering the optimal combinations of cells,biosignals,and scaffolds to produce tissue that emulates the char-acteristics of an undamaged,natural tendon.This review will cover various aspects,including the fabrication of tendon tissue scaffolds,the selection of seed cells,strategies for the modulation of healing-related biosignals,and provide a summary with prospective insights,aiming to enhance the comprehension of tissue engineering techniques in tendon injury repair and to in-spire innovative applications in this domain.
关键词
肌腱/损伤与修复/组织工程支架/种子细胞/生物信号
Key words
Tendon/Injury and repair/Tissue engineering scaffold/Seed cells/Biosignals
维普
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