Lung cancer is among the most prevalent malignant tumors globally,and bone metastasis frequently occurs during the course of lung cancer.Recently,the significance of the bone morphogenetic protein(BMP)signaling pathway in tumor growth,local tumor progression and bone metastasis of lung cancer has been discovered gradually.In this article the crucial function of the BMP pathway in the local progression of lung cancer and the process of lung cancer bone metastasis were reviewed in order to explicate the mechanism of the BMP signaling pathway in lung cancer bone metastasis and offer novel concepts and approaches for the targeted therapy of lung cancer.
关键词
骨形态发生蛋白/信号通路/肺癌/骨转移
Key words
Bone Morphogenetic Protein/Signaling Pathway/Lung Cancer/Bone Metastasis
维普
万方数据