Correlation analysis of cytokine levels with the severity and prognosis of ankle fractures
Objective:To investigate the correlation between the cytokine levels in peripheral blood of patients with ankle fractures and the severity and prognosis of ankle fractures.Methods:The clinical data of 86 patients with ankle fractures from June to December 2022 were retrospectively analyzed.According to the AO/OTA classification of ankle fractures,19 cases were categorized as type A(fibular fractures below the tibiofibular joint),38 cases as type B(fibular fractures involving the tibiofibular joint),and 29 cases as type C(fibular fractures above the tibiofibular joint).General information such as age,gender,body mass index(BMI),injury mode,time from admission to operation,operation duration,and intraoperative blood loss was collected.Enzyme-linked immunosorbent assays(ELISAs)were used to measure cytokine levels in the peripheral blood.The American Orthopedic Foot & Ankle Society(AOFAS)Ankle-Hindfoot Scale was used to evaluate the prognosis of ankle function.A total of 58 cases were effectively evaluated with the AOFAS Ankle-Hindfoot Scale at 12 months postoperatively,including 10 cases in the excellent group and 48 cases in the good group.The correlation between the cytokine levels in peripheral blood of the 58 patients and the severity and prognosis of ankle fractures was analyzed.Results:Peripheral blood levels of interleukin(IL)-6,IL-8,IL-10,and tumor necrosis factor-alpha(TNF-α)in patients with ankle fractures were correlated with the fracture severity(P＜0.01),with IL-6 exhibiting the strongest correlation(r=0.811,P＜0.01).Univariate analysis revealed that patients in the excellent group had shorter surgical durations,lower IL-6 levels,and higher IL-10 levels compared to those in the good group,with statistically significant differences(P＜0.05).Multivariate analysis revealed that surgical duration,IL-6,and IL-10 were independent risk factors influencing joint function in patients with ankle fractures(P＜0.05).Conclusions:Higher IL-6 levels in the peripheral blood correspond to more severe ankle fractures.IL-6 can serve as an important indicator for evaluating the fracture severity.Additionally,the IL-6 concentration is an independent risk factor for the prognosis of ankle fractures.Elevated IL-6 levels indicate poor long-term prognosis for joint function recovery,while elevated IL-10 levels are beneficial for joint function recovery.
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