三周期极小曲面骨支架生物学性能研究进展
Research progress on biological performance of triply periodic minimal surface bone scaffolds
孙亚迪 1王岩 1董本超 1杨培川 1李奕扬 1马天成 1马剑雄 1马信龙1
作者信息
- 1. 天津大学天津医院(天津市天津医院)骨科研究所,天津 300211;天津市骨科研究所,天津 300050;天津市骨科生物力学与医学工程重点实验室,天津 300050
- 折叠
摘要
由外伤和疾病所致的骨缺损患者逐年增多,而骨缺损的治疗仍然是临床上的一大难题.目前骨缺损的治疗手段主要包括自体骨移植和同种异体骨移植,然而这些方法的应用受到诸多限制.近年来,骨支架作为骨缺损修复的研究热点备受关注.三周期极小曲面(TPMS)骨支架作为构建骨支架的热门选择之一,其生物学性能成为当前研究的重点.渗透性、比表面积、生物相容性和生物降解性等因素被认为是影响TPMS骨支架生物学性能的关键因素.本文对TPMS骨支架生物学性能研究进展进行综述.
Abstract
The number of patients with bone defects caused by trauma and diseases has been increasing year by year.The treatment of bone defects remains a major challenge in clinical practice.Currently,the main treatment methods include autologous bone grafting and allogeneic bone grafting,but their application is hampered by several limitations.In recent years,bone scaffolds have attracted much attention as a research hotspot for bone defect repair.Among them,the triply periodic minimal surface(TPMS)bone scaffold is one of the popular choices for constructing bone scaffolds,and its biological performance has become a focus of current research.Parameters such as permeability,surface area ratio,biocompatibility,and degradability are considered the key determinants affecting the biological performance of TPMS bone scaffolds.This article reviews the research progress on the biological performance of TPMS bone scaffolds.
关键词
三周期极小曲面/骨支架/生物学性能/骨缺损Key words
Triply Periodic Minimal Surface/Bone Scaffolds/Biological Performance/Bone Defect引用本文复制引用
基金项目
国家重点研发计划(2022YFC3601900)
天津市自然科学基金重点项目(22JCZDJC00340)
天津市卫生健康科技项目(TJWJ2022QN053)
出版年
2024
NETL
NSTL
万方数据