Early clinical efficacy of artificial dermis combined with autologous platelet-rich plasma gel in repairing exposed bone/tendon wounds after trauma
Objective:To explore the early clinical efficacy of artificial dermis combined with autologous platelet-rich plasma gel(PRP)in repairing exposed bone/tendon wounds after trauma.Methods:A retrospective analysis was conducted on the clinical data of 36 patients who underwent repair of exposed bone/tendon wounds after trauma from January 2022 to June 2023.The study included 22 males and 14 females with an age range of 21 to 65 years(mean age 40.9±11.8 years).Twenty patients admitted from January to October 2022 were treated with artificial dermis and were designated the dermal treatment group,sixteen patients admitted from October 2022 to June 2023 were treated with artificial dermis combined with PRP gel and were designated the combined treatment group.The survival and healing time of the skin grafts were recorded in the two groups,and the scar hyperplasia in the grafted areas after treatment was compared between the two groups.Results:Both groups were followed up for more than 3 months after skin graft healing,with an average follow-up time of(4.5±1.3)months.The survival of the skin graft in the combined treatment group was significantly better than that in the dermal treatment group(P<0.05).The postoperative healing time of the skin graft in the combined treatment group was significantly shorter(24.37±3.48)d compared to the dermal treatment group(29.56±2.37)d(P<0.05).At 1 and 3 months after surgery,the Vancouver scar scale scores in the combined treatment group were significantly lower than those in the dermal treatment group(P<0.05).Conclusions:Repairing exposed bone/tendon wounds after trauma with a combination of artificial dermis and PRP gel achieved significant early clinical benifit,enhanced the survival rate of skin grafts,shortened the healing time of the skin graft areas,and reduced the severity of scar hyperplasia in the skin graft area,demonstrating its potential for clinical application.