磨损颗粒诱导人工关节置换术后假体无菌性松动相关生物学机制的研究进展
Research progress on the biological mechanism of wear particles induced prosthesis aseptic loosening after artificial joint replacement
李嘉欢 1乔永杰 2曾健康 3谭飞 3李培杰 3王伟 3宋晓阳 2祝朗峰 2李栋栋 2王静 3庄凯鹏 2周胜虎2
作者信息
- 1. 甘肃中医药大学,兰州 730030;中国人民解放军联勤保障部队第九四〇医院关节外科,兰州 730050
- 2. 中国人民解放军联勤保障部队第九四〇医院关节外科,兰州 730050
- 3. 甘肃中医药大学,兰州 730030
- 折叠
摘要
人工关节置换术是目前骨科最成功的手术之一,但术后假体无菌性松动是初次人工关节置换术后失败和行翻修手术的主要原因.假体无菌性松动是指在无外界创伤和感染的情况下,人工关节假体与骨骼之间发生的松动.本文主要从磨损颗粒对假体周围骨溶解的生物学机制出发,探讨了巨噬细胞、破骨细胞、成骨细胞、成纤维细胞等与假体无菌性松动的关系,以期为人工关节置换术后假体无菌性松动的预防和治疗提供理论依据.
Abstract
Artificial joint replacement is one of the most successful surgeries in orthopaedics.However,postoperative aseptic loosening of prostheses remains the leading cause of failure in both primary and revision surgeries.Aseptic loosening refers to the loosening that occurs between the artificial joint prostheses and bone in the absence of external trauma or infection.Based on the biological mechanism of wear particles in periprosthetic osteolysis,this article discusses the relationships among macrophages,osteoclasts,osteoblasts,and fibroblasts and aseptic loosening of prostheses,aiming to provide a theoretical basis for the prevention and treatment of aseptic loosening of prostheses after artificial joint replacement.
关键词
磨损颗粒/人工关节置换术/假体松动/骨溶解Key words
Wear Particles/Artificial Joint Replacement/Prosthesis Loosening/Osteolysis引用本文复制引用
基金项目
甘肃省重点研发计划(21YF5FA154)
甘肃省青年科技基金(20JR5RA588)
甘肃省青年科技基金(21JR7RA014)
部队专项培育项目(2021YXKY014)
兰州市科技计划(2023-2-11)
甘肃中医药大学导师专项(2023YXKY015)
出版年
2024
NETL
NSTL
万方数据