去整合素金属蛋白酶10介导的Notch信号通路在骨关节炎发病机制中的研究进展
Research progress on the role of a disintegrin and metalloproteinase 10-mediated Notch signaling pathway in the pathogenesis of osteoarthritis
李明阳 1曾羿 1聂涌 1吴元刚 1江胜虎 1沈彬1
作者信息
- 1. 四川大学华西医院骨科,骨科研究所,成都 610041
- 折叠
摘要
骨关节炎(OA)尚缺乏有效的治疗方式.众多研究表明,金属蛋白酶家族在OA发病机制中起着重要作用,或许能在OA治疗中发挥巨大作用.其中去整合素金属蛋白酶10(ADAM10)具有巨大潜力,其相关靶向药物已在临床上应用于其他疾病的治疗或者进行临床试验,如治疗阿尔茨海默病及免疫抑制.本文对ADAM10及其介导的Notch信号通路在OA发病机制中的研究进展进行综述,为ADAM10相关药物在OA治疗上的应用提供初步理论基础.
Abstract
Osteoarthritis(OA)remains a condition with limited effective treatment options.Extensive research has highlighted the significant role of the metalloproteinase family in the pathogenesis of OA,suggesting their potential as therapeutic targets.Among them,a disintegrin and metalloproteinase 10(ADAM10)has emerged as an promising candidate.Targeted drugs related to ADAM10 are either in use or currently undergoing clinical trials for various diseases,such as Alzheimer's disease and conditions requiring immune suppression.This article reviews the research progress on the role of the ADAM10-mediated Notch signaling pathway in the pathogenesis of OA,providing a theoretical basis for the"repurposing"of ADAM10-related drugs in the treatment of OA.
关键词
骨关节炎/去整合素金属蛋白酶10/Notch通路Key words
Osteoarthritis/A Disintegrin and Metalloproteinase 10/Notch Pathway引用本文复制引用
基金项目
四川省科技计划项目(2022YFS0050)
四川省自然科学基金(2023NSFSC1750)
四川大学博士后交叉学科创新启动基金(JCXK2217)
出版年
2024
NETL
NSTL
万方数据