Evaluation of a novel self-lengthening growing rod for early-onset scoliosis in a piglet model
Objectives:To evaluate the effectiveness of a novel self-lengthening growing rod in the treatment of scoliosis in a piglet model.Methods:Twelve 8-week-old male Yorkshire piglets were selected.Early-onset scoliosis models were established by implanting pedicle screws in the thoracic spine(T6-7)and lumbar spine(L2-3)and fixing with a single rod.Four weeks after successful modeling,the 12 piglets were randomly divided into a traditional growing rod group and a novel self-lengthening growing rod group,with six piglets in each group.The traditional growing rod group underwent lengthening surgery every two weeks for a total of eight weeks,whereas the novel growing rod group did not undergo any lengthening surgery.Anterolateral X-rays of the full-length spine were taken before,immediately after,and 8 weeks after rod implantation to measure the Cobb angle of the main coronal curve.Eight weeks after implantation,the extension length of the rods and the spinal growth length of the fixed segment were also measured.Results:Four weeks after modeling,the Cobb angle of the main coronal curve measured on the anterior-posterior X-rays was>10° in all piglets,indicating successful modeling.Two piglets in the traditional growing rod group were excluded due to deep wound infection and internal fixation loosening one week after the first lengthening surgery.No other animals experience infections or neurological complications.At 8 weeks post-implantation,the Cobb angle of the main coronal curve in the traditional growing rod group improved from 14.0°(11.5°,15.8°)pre-implantation to 3.0°(1.5°,3.8°),and in the novel growing rod group from 14.0°(12.5°,14.5°)to 3.5°(2.5°,4.0°),showing a significant corrective effect.There was no statistically significant difference in the sliding distance of the rods and the spinal growth length of the fixed segment between the two groups(both P>0.05).Conclusions:The novel self-lengthening growing rod can achieve effective scoliosis correction and promote spinal growth without the need for repeated lengthening surgeries in a piglet scoliosis model.
万方数据
维普
