Predictive value of the quantitative parameters of osteocalcin and procollagen Ⅰ N-terminal peptide combined with multi-slice spiral CT for the postoperative recurrence of osteoporotic vertebral compression fractures
Objective:To investigate the predictive value of quantitative parameters of osteocalcin (BGP) and procollagen Ⅰ N-terminal peptide (PⅠNP) combined with multi-slice spiral CT (MSCT) for the postoperative recurrence of osteoporotic vertebral compression fracture (OVCF). Methods:A total of 168 patients with OVCF who underwent percutaneous kyphoplasty (PKP) at the Affiliated Qingdao Third People's Hospital of Qingdao University from December 2020 to February 2022. Patients were divided into a recurrence group (62 cases) and a non-recurrence group (106 cases) based on postoperative follow-up results. Enzyme-linked immunosorbent assay (ELISA) was performed to detect serum BGP and PⅠNP in patients before surgery,and MSCT was used to collect bone volume fraction (BV/TV),trabecular bone thickness (Tb.Th),trabecular bone gap (Tb.Sp),and structural model index (SMI). Clinical data,along with BGP,PⅠNP and MSCT quantitative parameters were compared between two groups,and logistic regression analysis was used to identify the influencing factors of postoperative recurrence. The receiver operating characteristic (ROC) curves were employed to assess the predictive value of the BGP,PⅠNP,and MSCT quantitative parameters for postoperative recurrence. Results:The recurrence group had higher rate of bone cement leakage,elevated levels of BGP,PⅠNP,increased Tb.Sp,and SMI compared to the non-recurrence group,the recurrence group also had a lower proportion of postoperative anti-osteoporosis treatment,and a lower BV/TV and Tb.Th (all P<0.05). Multivariate logistic regression analysis revealed that BGP,PⅠNP,Tb.Sp,and SMI were risk factors for postoperative recurrence,while BV/TV and Tb.Th were protective factors (all P<0.05). ROC analysis showed that the areas under the curve (AUC) for serum BGP,PⅠNP,BV/TV,Tb.Sp,Tb.Th,SMI and their combined prediction were 0.930,0.836,0.837,0.741,0.805,0.782,and 0.960,respectively. AUC comparison revealed that the combined prediction was superior to the individual prediction (Z=3.892,4.006,3.793,5.561,4.557,and 5.003;all P<0.05). Conclusions:The combination of BGP,PⅠNP and MSCT quantitative parameters may have high predictive value for postoperative recurrence of OVCF and can provide a reference for the prediction of postoperative recurrence in clinical patients.
万方数据
维普
