Bone morphogenetic protein (BMP) are a class of growth factors that regulate cellular functions and are essential for processes such as embryonic development,tissue and organ differentiation,and bone formation. The BMP pathway has been proven to be closely related to the occurrence of tumors. Prostate carcinoma (PC) is one of the common malignant tumors in men worldwide,and bone metastasis is common in advanced PC. Once bone-related events occur,patients' quality of life and prognosis can severely be affected. Currently,the regulatory mechanisms of the occurrence and progression of PC bone metastasis remain unclear. This article summarizes the mechanisms of the BMP pathway in the process of PC bone metastasis,providing a theoretical basis and reference for the early diagnosis and targeted treatment of PC bone metastasis.
关键词
骨形态发生蛋白/骨形态发生蛋白通路/前列腺癌/骨转移
Key words
Bone Morphogenetic Protein/Bone Morphogenetic Protein Pathway/Prostate Carcinoma/Bone Metastasis
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