Objective To investigate the effects of doxofylline combined with terbutaline on inflammatory level and lung function in pneumoconiosis patients with whole lung lavage.Methods This was a retrospective analysis of the medical records of 45 patients with pneumoconiosis who underwent large-volume whole lung lavage surgery in our hospital from June 2021 to Feb-ruary 2023,among them,23 patients only received doxofylline treatment were divided into control group,and another 22 patients who received both doxofylline and terbutaline treatment were divided into observation group.Compare the clinical data,lung function indexes,inflammatory factor levels and blood gas analysis indexes of two groups of patients,then evaluate the improve-ment of lung function and inflammatory factor levels of the patients between two groups using a random walking model.Results The results showed that there was no significant difference in lung function such as FVC,FEV1.0/FVC and MVV between two groups before treatment(P＞0.05),but after treatment,these lung function indexes were all significantly higher than those before treatment(P＜0.05),and these indicators in observation group were significantly higher than that of control group(P＜0.05);compared with preoperation,the serum levels of IL-6 and TNF-α in patients of both groups decreased significantly,the levels of TGF-β1 was significanly increased,and these improvements in observation group was more obvious than that in the control group(P＜0.05);after operation,PaO2 significantly increased,PA-aO2 and PaCO2 significantly decreased in both two groups,the im-provement of these indicators in observation group was also more significant than that of the control group(P＜0.05);additionally,there was a significant positively correlation between TGF-βl and FVC,FEV1.0/FVC,MVV,as well as a negatively correlation with IL-6 and TNF-α(P＜0.05),furthermore,the generalized estimation equation analysis evaluation showed that the improve-ment of each these various indexes in observation group was obviously better than that in control group.Conclusion The results suggested that TGF-β1 showed positively correlation with lung function indexes in pneumoconiosis patients,and the combination application of doxofylline and terbutaline had a better effect on improving lung function,blood gas analysis indicators and serum levels of inflammatory factors in pneumoconiosis patients after large-volume whole lung lavage than doxofylline alone.
维普
万方数据