不同运动分型对帕金森病患者骨质疏松发生的影响
Effect of different exercise types on osteoporosis in patients with Parkinson's disease
许富贵 1乙红艳 1欧洲 1王丽君 1杨秀 1魏明 1薛刘军 1佟强1
作者信息
- 1. 南京医科大学附属淮安第一医院神经内科,江苏 淮安 223300
- 折叠
摘要
目的 探讨帕金森病(parkinson disease,PD)患者不同运动亚型对骨质疏松发生的影响.方法 选取 2021 年 7 月至2023 年2 月于南京医科大学附属淮安第一医院神经内科就诊的PD患者101 例,进行统一帕金森评定量表(UPDRS)Ⅲ、PD患者生活质量问卷(PDQ-39)等评分,依据UPDRS Ⅲ评分将PD患者分为震颤为主型(tremor-dominant,TD型)和少动-强直为主型(akinetic-rigid dominant,ARD型),比较不同运动亚型PD患者骨质疏松发生情况,探讨其潜在的危险因素.结果 ①少动-强直组的骨质疏松发生率、PDQ39 项、HAMA、HAMD-24 评分均高于震颤组,差异具有统计学意义(P＜0.05).②骨质疏松组女性比例、少动-强直型比例、UPDRS Ⅲ评分、PDQ39 项、HAMA、HAMD-24 高于非骨质疏松组,差异具有统计学意义(P＜0.05).③相关分析示PD患者骨质疏松发生与女性(r=0.34,P＜0.001)、少动-强直型(r=0.31,P=0.002)、UPDRS Ⅲ评分(r=0.43,P＜0.001)均呈正相关.④二元Logistic回归分析显示,女性(OR=3.06,95%CI:1.18～7.94,P=0.022)、少动-强直亚型(OR=4.53,95%CI:1.70～12.09,P=0.003)、UPDRS Ⅲ评分(OR=1.11,95%CI:1.04～1.19,P=0.001)是PD发生骨质疏松的独立危险因素.结论 PD少动-强直亚型与骨质疏松的发生密切相关,严重影响PD患者的生活质量.
Abstract
Objective To explore the effect of different motor subtypes on osteoporosis in patients with Parkinson's disease.Methods A total of 101 patients with Parkinson's disease who were admitted to the Department of Neurology,the Affiliated Huai'an First People's Hospital of Nanjing Medical University from July 2021 to February 2023 were selected and scored on the Unified Parkinson's Rating Scale(UPDRS)Ⅲ and the Parkinson's Disease Quality of Life Questionnaire(PDQ-39).Patients with Parkinson's disease were classified into tremor-dominant type and akinetic-rigid dominant type based on UPDRSⅢscores.The differences of osteoporosis incidence in patients with akinetic-rigid dominant(ARD)were compared to those with tremor-dominant type.The potential risk factors were explored.Results(1)The incidence of osteoporosis,PDQ39,HAMA,and HAMD-24 in ARD type were higher than those in TD type,and the difference was statistically significant(P＜0.05).(2)The female proportion,ARD proportion,UPDRSⅢ score,PDQ39,HAMA,and HAMD-24 in osteoporosis group were higher than those in non-osteoporosis group,and the differences were statistically significant(P＜0.05).(3)Correlation analysis showed that the incidence of osteoporosis in PD patients was positively correlated with female(r=0.34,P＜0.001),ARD type(r= 0.31,P= 0.002),and UPDRSⅢ score(r=0.43,P＜0.001).(4)Binary Logistic regression analysis showed that the female(OR=3.06,95%CI:1.18-7.94,P=0.022),ARD type(OR=4.53,95%CI:1.70-12.09,P=0.003),UPDRSⅢ score(OR=1.11,95%CI:1.04-1.19,P=0.001)were independent risk factors for osteoporosis in PD.Conclusion The ARD type of Parkinson's disease is closely related to the occurrence of osteoporosis,which seriously affects the quality of life of patients with Parkinson's disease.
关键词
帕金森病/骨质疏松/运动亚型Key words
Parkinson's disease/osteoporosis/motor subtypes引用本文复制引用
基金项目
国家自然科学基金青年科学基金(81600981)
江苏省自然科学基金面上项目(BK20191212)
江苏省卫生健康委科研项目(M2022082)
淮安市心脑血管病重点实验室项目(HAP202202)
出版年
2024
NETL
NSTL
维普
万方数据