Molecular biology research on osteoporosis has made progress in the fields of bone metabolism molecular signaling pathways,osteoporosis susceptibility genes,osteoporosis related proteins,and targeted treatment of osteoporosis.RANKL/RANK/OPG,NF-κB,MAPK/ERK,M-CSF,Ca2+,Src,Akt,PKC signaling pathway and other important bone metabolism pathways,susceptible genes such as VDR gene,LRP5 gene,MTHFR gene,ER gene,etc.As well as related proteins such as Apo E,Klotho protein,BMP,and BSP,etc.They directly or indirectly participate in the regulation of bone metabolism,with overlapping and interrelated effects,Consensus has been reached in this professional field.
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